| 摘要 |
1524574 Silylated prostaglandin precursors IMPERIAL CHEMICAL INDUSTRIES Ltd 22 June 1976 [30 July 1975] 31928/75 Heading C3S [Also in Division C2] 4# - [4 - (3 - Chlorophenoxy) - 3alpha - hydroxybuttrans - 1 - enyl] - 3,3alpha#,4,5,6,6alpha# - hexahydro- 5alpha - trimethylsilyloxy - 2H - cyclopenta[b]- furan-2-ol is prepared by reducing 4#-[4-(3- chlorophenoxy) - 3alpha - hydroxybut - trans - 1 - enyl] - 3,3alpha#,4,5,5,6alpha# - hexahydro - 5alpha - trimethylsilyloxy - 2H - cyclopenta[b]furan - 2 - one, obtained by reducing 4#-[4-(3-chlorophenoxy-3-oxobut - trans 1 - enyl] - 3,3alpha#,4,- 5,6,6alpha# - hexahydro - 5alpha - trimethylsilyloxy- 2H - cyclopenta[b]furan - 2 - one, which is made by reacting 4# - [4 - (3 - chloropophenoxy)- 3 - oxobut - trans 1 - enyl] - 3,3alpha#, 4,5,6,6alpha#- hexahydro - 5alpha - hydroxy - 2H - cyclopenta[b]- furan-2-one with hexamethyldisilazone and trimethylchlorosilane. 4# - (4 - (3 - Chlorophenoxy) - 3alpha - trimethylsilyloxybut - trans - 1 - enyl] - 3,3alpha#,4,5,6,6alpha#- hexahydro - 5alpha - trimethyl - silyloxy - 2H - cyclopenta[b]furan - 2 - ol is prepared by reducing 4# - [4 - (3 - chlorophenoxy) - 3alpha - trimethylsilyloxybut - trans - 1 - enyl] - 3,3alpha#,4,5,- 6,6alpha# - hexahydro - 5alpha - trimethylsilyloxy - 2H- cyclopenta[b]furan - 2 - one, resulting from the reaction between 4# - [4 - (3 - chlorophenoxy- 3alpha - hydroxybut - trans 1 - enyl] - 3,3alpha#,4,5,- 6,6alpha# - hexahydro - 5alpha - hydroxy - 2H - cyclopenta[b]furan - 2 - one, hexamethyldisilazane and trimethylchlorosilane. Reference has been directed by the Comptroller to Specifications 1,040,544, 1,285,372, 1,350,971, 1,372,541, 1,392,991, 1,398,838, 1,409,841 and 1,428,137. |
