PROCESS FOR THE PREPARATION OF N-(1-ETHYL-2-PYRROLIDYLMETHYL)-2-METHOXY-5-SULFONAMOLY BENZAMIDE

摘要

There is provided a novel method for preparing N(1-ethyl-2-pyrrolidylmethyl)-2-methoxy-5-sulphamoyl benzamide, its acid addition salts with pharmaceutically acceptable inorganic or organic acids and its quaternary ammonium salts, characterized in that an enamine of the general formula: wherein R1 represents an organic group, and R2 represents an acyl group, or salts thereof, is reacted with a 2-methoxy-5-sulphamoyl benzoic acid or one of its reactive derivative. The product prepared is an antiemetic.