| 摘要 |
<p>NEW MATERIAL:A compound isolated by column chromatography from a solution of crude venom of a habu, having an absorption maximum at 278nm in the ultraviolet region, a molecular weight of 28,000-32,000, comprising a water-soluble glycoprotein with the total nitrogen content of 12.4+ or -1%. USE:Treating agents for thrombotic and embolic diseases. PROCESS:A solution of crude venom of a habu is subjected to column chromatography with Sephadex G-75 or G-100, and CM cellulose, then Sephadex G-50. The fraction having the greatest fibrinolytic activity is obtained by using a buffer consisting of an electrolyte of pH 6-8 as the objective component.</p> |
