| 摘要 |
<p>Disclosed are compounds of the formula wherein R1, R2 are H, lower alkyl, lower alkoxy, hydroxyl, fluorine, chlorine, bromine, trifluoromethyl, 2,2,2-trifluoroethyl, methylthio, trifluoromethylthio, trifluoromethylsulfonyl, methylsulfonyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, carbamoyl, sulfamyl, N-methylsulfamyl, N,N-dimethyl-sulfamyl, methylsulfinyl, hydrazinocarbonyl, hydroxylamincarbonyl, lower alkylcarbonyl, cycloalkylcarbonyl of 4-7 carbons, nitro, and where R is H, alkyl of uo to 10 carbon atoms, alkenyl of 3-7 carbon atoms attached by a saturated carbon atom to N, cycloalkyl, of 3-5 carbon atoms, propargyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-penta-fluoropropyl, .alpha.-furylmethyl, .alpha.-thienyl-methyl, -(CH2)nCN, -(CH2)nCO2H, -(CH2)qOR3,-(CH2)nCO2 (lower alkyl) and -CH(R4) (CH2)pR5 of uo to 14 carbons, where q is 2-6; n is 1-6; p is 0-5; R3 is lower alkyl, phenyl or lower alkylphenyl; R4 is H or n-lower alkyl; R5 is a hydrocarbyl group containing at least one ring of 3-9 carbon atoms attached to alkylene by a ring carbon atom, with the proviso that when p is O, the carbon atom attached to -CH(R4)- is not a quaternary carbon atom; and, when R is other than H, the nitrogen atom can be additionally substituted with oxygen to form a tertiary amine oxide, made by rearrangement of 9,12-bridged ethencanthracenes. The compounds where R is other than H are useful as tranquilizing agents and analgesics in warmblooded animals. - 1a</p> |
