Isomerisation of 3-azabicyclo(3.1.0)hexane derivatives.

摘要

A process for the isomerisation of a cis or trans 2-cyano-3-azabicyclo[3.1.0]hexane, wherein a compound of the general formula <CHEM> wherein the group CN and the <CHEM> moiety are in a cis or trans configuration and R1, R2, R3 and R4 each independently represents a hydrogen or halogen atom or an alkyl group with up to 6 carbon atoms which may optionally be substituted by up to 3 halogen atoms, is contacted with a solvent in the presence of a compound containing, or capable under the isomerisation conditions of generating, free cyanide moieties.