| 摘要 |
<p>A process for the manufacture of a substantially isomerically pure acylanilide of the structure <CHEM> where R is hydrogen, lower alkyl, hydroxy-lower alkyl or lower alkoxy-lower alkyl; R1 is lower-alkyl, phenyl, lower-alkylphenyl, lower alkoxy, lower alkoxyphenyl, chlorophenyl, nitrophenyl, dichlorophenyl, choro-lower alkyl, cyano-lower alkyl, lower alkyl, amino, sulfamoylphenyl, carbamoylphenyl or lower alkoxy-lower alkyl; and X is -CO- or -SO2-; comprising the step of treating an alcohol solution of a diamino compound of the structure <CHEM> with an acylating agent, to give an alcohol solution of the acylanilide, wherein substantially equivalent amounts of the acylating agent and the diamino compound are used and therein the treatment is carried out by the slow, drop-wise addition of the acylating agent at a temperature in the range of about 0 to 5 DEG C. The process is particularly advantageous when the alcohol solution of the diamino compound is produced by reduction of a suspension of the corresponding dinitro compound in the alcohol.</p> |
