| 摘要 |
The invention relates to an anticoagulant agent which acts without cofactor and selectively inhibits thrombin, and to pharmaceutical preparations containing said agent. The anticoagulant agent is prepared by sulphatation of a polysaccharide obtained by precipitation from the decoction of mollusca, preferably common sea mussels. Sulphatation is preferably achieved with chlorosulphonic acid in the presence of pyridine. |
