N-METHANESULFONIC ACID DERIVATIVES OF 3',4'-DIDESOXYKANAMYCIN B AND THE METHOD FOR PRODUCTION THEREOF

摘要

N-METHANESULFONIC ACID DERIVATIVES OF 3',4'-DIDEOXYKANAMYCIN B AND THE METHOD FOR PRODUCTION THEREOF As new semi-synthetic antibiotic derivative are provided N-methanesulfonic acid derivatives of 3',4'dideoxykanamycin B which are less toxic than the parent antibiotic and have useful high antibacterial activity. They are produced by interacting 3',4'-dideoxykanamycin B, an aldehyde such as paraformaldehyde and sulfurous acid or an alkali metal sulfite reagent.