NYA ACYL-1H-1,2,4-TRIAZOLDERIVAT

摘要

New acyl-1H-1,2,4-triazole derivatives of the formula I wherein R may be located on one of the two adjacent nitrogen atoms and may represent hydrogen; a group R5-CO wherein R5 is selected from (C1-4)alkyl, (C2-4)alkenyl, (C2-4)alkynyl, phenyl, phenyl substituted by one to three groups independently selected from halo, (C1-4)alkyl, (C1-4)alkoxy, trifluoromethyl, cyano, nitro, amino, di-(C1-4)alkylamino, (C2-4)acylamino and methylenedioxy, benzyl, cinnamyl, amino, (C1-4)alkylamino, di-(C1-C4)alkylamino, phenylamino, phenylamino wherein the phenyl ring may be substituted by one to three groups independently selected from halo, (C1-4)alkyl, (C1-4)alkoxy, trifluoromethyl, cyano, nitro, amino, di-(C1-4)alkylamino, (C2-4)acylamino and methylenedioxy, halo(C1-4)alkyl, (C1-4)alkoxy and benzyloxy; a group R6-SO2 wherein R6 may represent (C1-4)alkyl, phenyl, phenyl substituted by a radical selected from (C1-4)alkyl and (C1-4)alkoxy, or phenacyl; R1 is selected from hydrogen, (C1-4)alkyl, (C1-4)alkoxy, allyloxy, propargyloxy, trifluoromethyl, phenyl, halo and dimethylamino; R2 may represent a (C1-4)alkyl radical or the group wherein R7 is hydrogen or methyl and R8 is a (C1-4)alkyl radical, the group R5-CO or the group R6-SO2 in which R5 and R6 are defined as above, or R7 and R8 taken together may represent a further bond between the carbon and oxygen atom; R3 and R4 are independently selected from hydrogen, halo, (C1-4)alkyl and (C1-4)alkoxy; R1 and R4 taken together may also represent a methylenedioxy group; with the proviso that, when R represents hydrogen, R2 must be the group in which R8 must be the group R5-CO or the group R6-SO2 wherein R5 and R6 are as above defined; and salts therewith of pharmaceutically acceptable acids. The compounds possess antireproductive utility.