METHOD OF ISOLATION OF THE WATER SOLUTIONS COMPONENTS

摘要

1467599 Chromatographic concentration MERCK PATENT GmbH 27 Feb 1975 [2 March 1974] 822875 Heading B1H [Also in Divisions Cl and G1] Components present in aqueous solution, for example drugs or drug metabolites in body fluids are isolated for analysis by adsorption of the components on a concentration agent comprising silica gel and/or Kieselguhr and subsequent extraction of the components with a lipophilic solvent, the concentration agent being a flowable silica gel and/or kieselguhr with an average particle size of 0.05 to 1.0 mm, and average pore volume of 0.2 to 3 ml/g and a specific surface of 0.2 to 50 m2/g. The concentration agent may be used as a column packing in a glass or synthetic resin column length 5 to 20 cm, diameter 1 to 3 cm, the packing being retained by wadding or polypropylene mesh. The column may be a syringe barrel. Alternatively the packing may be in pillow- or sphere-shaped bags.