3,7-Disubstituted-2- or -3-cephem-4-carboxylic acid compounds, pharmaceutical compositions containing them and processes for the preparation thereof.

摘要

New 3,7-disubstituted-2 or 3-cephem-4-carboxylic acid compounds of the formula:
<CHEM>
wherein
R<1> is amino or a substituted amino group;
R<2> is carboxy or a protected carboxy group;
the group of the formula:
<CHEM>
is di(lower)alkylamino (lower)alkylamino, a N-containing heterocyclic (lower)alkylamino group which may have suitable substituent(s), a heterocyclic group containing 2 to 4 nitrogen atoms which may have suitable substituent(s) or hydroxypiperidino; and X is -S- or 0;
-S- e.g. 7-[2-methoxyimino-2- (2-aminothiazol-4-yl) acetamido] -3-(4-methyl-1-piperazinyl) carbonyloxymethyl-3-cephem -4-carboxylic acid (syn isomer); pharmaceutically acceptable salts thereof; and processes for their preparation. The invention also relates to pharmaceutical compositions comprising, as an effective ingredient, the above compounds in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient; and to a process for their preparation.