发明名称 |
Derivatives of 3-carboxyrifamycin S and SV and process for their preparation |
摘要 |
New compounds being derivatives of 3-carboxyrifamycin S and SV are prepared by oxidation of cyanohydrin of 3-formylrifamycin S to 3-(cyanocarbonyl)rifamycin S, condensation with a compound of formula HR (an alcohol, an amine or an substituted hydrazine) and, optionally, reduction of the derivative of 3-carboxyrifamycin S so obtained to the corresponding SV form. Alternatively 3-(cyanocarbonyl)rifamycin S may be converted to the SV form before condensing with the compound HR.
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申请公布号 |
US4200573(A) |
申请公布日期 |
1980.04.29 |
申请号 |
US19780968409 |
申请日期 |
1978.12.11 |
申请人 |
ALFA FARMACEUTICI S.P.A. |
发明人 |
BELLOMO, PIERFRANCO;BRUFANI, MARIO;MARCHI, EGIDIO;MASCELLANI, GIUSEPPE |
分类号 |
A61K31/395;A61P31/04;C07D498/08;(IPC1-7):C07D491/08;A61K31/33 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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