Process for the production of 3-aminoisoxazoles

摘要

3-Aminoisoxazoles of the formula: <IMAGE> (wherein R is C1-C6 alkyl, phenyl or halo-phenyl) are prepared by reacting a beta -ketonitrile of the formula: R-CO-CH2CN (wherein R is as defined above) with a compound of the formula: HY (wherein Y is C1-C6 alkoxy or C1-C6 alkylthio) in the presence of an acid in a solvent to give an iminium salt of the formula: <IMAGE> (wherein X is the residue of said acid; R and Y are each as defined above) and further reacting the iminium salt with hydroxylamine in an inert solvent.