PROCESS FOR PREPARING THIOUREA, GUANIDINE AND 2,2-DIAMINO-1-NITROETHYLENE DERIVATIVES

摘要

Pharmacologically active compounds are disclosed of the formula: wherein X is sulphur, CHNO2, N.CN or NH; Y is amino (except when X is N.CN), lower alkoxy, phenylethyl, imidazolylethyl, allyl, trifluoroethyl or (CH2)nR; Z is sulphur or methylene; Het is an imidazole, pyridine, thiazole, isothiazole, oxazole, isoxazole, triazole or thiadiazole ring which ring is optionally substituted by lower alkyl, hydroxy, halogen or amino; n is an integer from 1 to 12; and R is hydroxy, lower alkoxy, amino or lower alkylamino; provided that when X is NH, Y is trifluoroethyl or (CH2)nR. These compounds find use as histamine H2-antagonists.