N-Substituted amino glycoside compounds, their production, and their use as medicaments

摘要

The invention relates to new derivatives, substituted on one or more nitrogen atoms, of 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols, which include the gentamycins, sisomicin, verdamycin, tobramycin, the kanamycins, the antibiotics G-418, 66-40 B, 66-40 D, JI-20 B, JI-20 B and G-52, and the 5-epi-, 5-epi-amino-5-deoxy and 5-epi-azido-5-deoxy derivatives of these antibiotics and the metamycins, and furthermore to processes for the preparation of these derivatives and to pharmaceutical compositions which contain the derivatives of the above mentioned 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols or their pharmaceutically acceptable acid addition salts, and to their use as antibacterial agents.