发明名称 |
PROCESS FOR THE PREPARATION OF SUBSTITUTED GUANIDINE COMPOUNDS |
摘要 |
<p>A process for the production of compounds having activity as histamine H2-receptor antagonists and having the formula where Y is a lower alkyl group, and pharmaceutically acceptable acid addition salts thereof, in which 4-hydroxy-methyl-5-(2-aminoethyl)thiomethylimidazole is reacted with a dilower alkyl dithioiminocarbonate which is subsequently reacted with an amine of formula YNH2. The salts can be prepared by known methods.</p> |
申请公布号 |
CA1075702(A) |
申请公布日期 |
1980.04.15 |
申请号 |
CA19760257589 |
申请日期 |
1976.07.22 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LIMITED |
发明人 |
WHITE, GEORGE R. |
分类号 |
C07D233/66;A61K31/4164;A61K31/44;A61K31/4427;A61P43/00;C07D233/54;C07D233/64;C07D233/90;C07D401/12;(IPC1-7):07D233/64 |
主分类号 |
C07D233/66 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|