发明名称 3-HETEROTHIO-7-THIOUREIDO CEPHALOSPORINS
摘要 <p>Compounds of the formula wherein R is hydrogen or methoxy; R1 is hydrogen, lower alkyl, cyclo-lower alkyl, cyclo-lower alkenyl, cyclo-lower alkadienyl, thienyl, furyl, phenyl, phenyl-lower alkyl, or substituted phenyl wherein said phenyl substituent is halogen, hydroxy, amino, lower alkyl or lower alkoxy; R2 is hydrogen, lower alkyl, lower alkenyl, cyclo-lower alkyl or lower alkanoyl; R3 is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion, or ; R5 is lower alkyl, phenyl or phenyl-lower alkyl; R6 is hydrogen or lower alkyl and R4 is a 5- or 6-membered heterocyclic ring containing carbon and 1 to 4 atoms selected from the group consisting of nitrogen, sulfur and oxygen, unsubstituted or substituted with one lower alkyl, lower alkoxy, halogen or exocyclic oxygen, are useful as antibacterial agents.</p>
申请公布号 CA1075679(A) 申请公布日期 1980.04.15
申请号 CA19760255829 申请日期 1976.06.28
申请人 E.R. SQUIBB & SONS, INC. 发明人 BREUER, HERMANN;TREUNER, UWE D.
分类号 A61K31/545;A61K31/546;A61P31/04;C07D501/04;C07D501/06;C07D501/36;C07D501/57;C07F7/22;(IPC1-7):07D501/36 主分类号 A61K31/545
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