| 摘要 |
<p>NEW MATERIAL:A compound of formula I (R<1> is H or lower alkyl group; R<2> is an alkyl group which may be substituted; R<3> is lower alkyl group; n is 0, 1, or 2; R'' is an organic group which is linked to each other via 0 or S; R<5> is H or carboxyl- protecting group), and its salt. EXAMPLE:7beta-[D-alpha-( 4-Ethyl-2, 3-dioxo-1-piperazine-carboxamido )-beta-hydroxypropanamido]-7alpha-methoxy-3-[5-( 1-methyl-1,2,3,4-tetrazolyl )thiomethyl]-DELTA<3>-cephem- 4-carboxylic acid. USE:An antibacterial having a wide antibacterial activity, stable to beta-lactamase. PROCESS:A compound of formula II is reacted with a reactive derivative of a compound of formula III in an inert solvent at -60-80 deg.C to give the compound of formula I.</p> |
