摘要 |
Compounds of the formula <IMAGE> and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R1 and R2 independently are hydrogen or C1-C3 primary alkyl; R3 is C1-C4 primary or secondary alkyl or -CH2CH2-S-CH3; R4 is hydrogen or C1-C3 primary alkyl; R5 is hydrogen or C1-C3 primary alkyl; Y is hydrogen or acetyl; and Z is <IMAGE> -CH2OH, or -CN; subject to the limitation that no more than one of R4 and R5 is C1-C3 primary alkyl; are useful analgesic agents. |