| 摘要 |
Heterocyclic derivatives of guanidine selected from the group consisting of a compound having the formula: <CHEM> and the pharmaceutically acceptable acid addition salts thereof wherein; Z is selected from the groups <CHEM> wherein: A is O and S; n is zero or 1; R1 is methyl and ethyl; R2 is loweralkyl, cyclopentyl, cyclohexyl and benzyl; <CHEM> wherein W is O, S, N-loweralkyl and N-aryl; and R3 is alkyl having from 4 to 10 carbons; phenyl; methylenedioxyphenyl; phenyl substituted with from 1 to 3 substituents consisting of halo, loweralkyl, and loweralkoxy; and phenyl substituted with hydroxy, benzyloxy, nitro: trifluoromethyl and methylthio; naphthyl; cyclopentyl; cyclohexyl; exo-2-norbornyl; endo-2-norbornyl; 1-adamantyl; arylalkyl in which the aryl function is phenyl and the alkyl function has from 1 to 4 carbons; and diphenylalkyl in which the alkyl function has from 1 to 2 carbons, possess pharmacological properties, particularly as hypoglycemic agents.
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