发明名称 Fluorination process and fluoro analogs of hydrocodone and oxycodone.
摘要 Compounds of the formula <CHEM> wherein R is selected from the group consisting of hydrogen, alkyl of 1-10 carbon atoms, ally, methylallyl, dimethylallyl, cycloalkylmethyl of 4-7 carbon atoms, 2-furanylmethyl, 2-tetrahydrofuranylmethyl, 2-thenylmethyl, 2-thienylethyl and phenylethyl which may be ring substituted with chloro, bromo, fluoro, methoxy or 1-3 carbon alkyl substituents; Y is H or R min ; R min is selected from the group consisting of alkyl of 1-4 carbons and alkanoyl of 1-12 carbons; R min is selected from the group consisting of hydrogen, hydroxy and alkanoate of 1-4 carbons; n is 1 or 2; and a is a 6,7 double bond when n = 1, and a single bond when n = 2; and pharmaceutically acceptable salts of the compounds.
申请公布号 EP0009227(A1) 申请公布日期 1980.04.02
申请号 EP19790103475 申请日期 1979.09.17
申请人 E.I. DU PONT DE NEMOURS AND COMPANY 发明人 BOSWELL, GEORGE ALBERT;HENDERSON, ROSETTA MCKINLEY
分类号 C07D221/28;C07D489/00;C07D489/02;C07D489/08;(IPC1-7):C07D489/00 主分类号 C07D221/28
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