CYTOTOXISCHE PRODUKTEN GEVORMD DOOR COVALENTE BINDING VAN DE A-KETEN VAN RICINUS MET EEN ANTI-LICHAAM ALSMEDE WERKWIJZE TER BEREIDING DAARVAN.

摘要

Carcinostatic products are formed by coupling, by covalent bonding, the A chain of ricin with an antibody which is capable of selectively recognizing a given antigen at the surface of cancerous cells. Such products can be made by the formation of a disulphide bridge between the free thiol group in the A chain of ricin and an immunoglobulin or immunoglobulin fragment into which a thiol group or an activated disulphide group has been introduced. The A chain of ricin and the immunoglobulin are carefully purified before use.