Production of nanaomycin A and derivatives thereof

摘要

The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: (I) in which (a) R is H and R' is OH (nanaomycin A), (b) R is H and R' is NH2 (nanaomycin C), (c) R is COCH3 and R' is CH (acetylnanaomycin A), and (d) R is H and R' is OCH3 (nanaomycin A methyl ester). Nanaomycin A is a new compound of quinone type and its acute toxicity (LD50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A.