| 摘要 |
<p>The present invention provides processes for the production of new basically substituted alkoxypyridinecarboxamides of the general formula I (I) wherein R1 represents alkyl containing 1 to 4 carbon atoms and -OR1 is in adjacent position to the carboxamide group, R2 represents alkyl containing 1 to 4 carbon atoms or an ethylene radical which is attached to one of the trivalent radicals designated as A and the nitrogen atom located between it to form a 6-membered ring, A represents trimethylene or tetramethylene, if R2 is alkyl as defined above, or, if R2 is an ethylene radical, represents the 1-propanyl-3-ylidene radical linked in its 1-position with the nitrogen atom, if m is 1, or the 1,2,4-butane-triyl radical linked in its 4-position with the nitrogen atom and in its 2-position with R2, if m is 0, and one of the factors m and n is 0 and the other is 1, and the ring B is substituted only by OR1 or additionally by halogen with an atomic number up to 35, alkyl containing 1 to 4 carbon atoms and/or alkoxy containing 1 to 4 carbon atoms, and of acid addition salts thereof. These new substances possess valuable pharmacological properties, in particular antiemetic, psychosomatic and antipsyehotic activity and can be used for the treatment of thought disturbances and of states of psychomotor excitation.</p> |
