摘要 |
<p>Phenylene bis-(aminoethers). Cpds. (I), useful as antiarrhythmic and beta-sympatholytic agents and local anaesthetics: (where R is 1-6C alkyl and X is H, one or more halogen, 1-6C alkyl, -alkoxy, -acylamino or -acyl, 2-6C-alkenyl or -alkynyl, aryl-(1-6C-alkyl), OH, CN or NO2) are prepd. either by ether formation or by aminating the corresponding halo or epoxy deriv. or by alkylating (I, R=H).</p> |