| 摘要 |
NEW MATERIAL:1-HYDROXY-13-dihydro-daunomycin and N-formyl-1-hydroxy- 13- dihydrodaunomycin of formula I: (R is H or CHO group) and their acid addition salts. USE:Carcinostatics. PROCESS:epsilon-pyrromycinone or epsilon-isorhodomycinone of formula II (R is H or OH) is converted by strains of daunomycin-producing bacteria or their variation ones varied with ultraviolet light, e.g. Streptomyces coelureorubidus ME 130-A4 (FERM- P No.3540). particularly variation strains producing no pigment, e.g. Streptomyces coelureorubidus E-130-1u-222, to give the objective compound of formula I. |
