| 摘要 |
<p>NEW MATERIAL:A compound of formula I or II(R1 is alkoxy or OH; R2 is H or protecting group; R3 is alkyl; R4 is OH, SH, alkylthio or NH2). EXAMPLE:1-(2-Deoxy-2-methylthio-beta-D-arabinofuranosyl)-O<2>-methylur acil. USE:Reagent for biochemical research. Possible anti-tumor and anti-viral agent. An intermediate of 5'-triphosphoric acid derivative which is expected as an inhibitor of DNA-synthetase. A reagent for the investigation of the metabolism of a nucleic acid- relating substance such as an anti-viral agent, 1-(2-deoxy-2-methoxy-beta-D-arabinofuranosyl)uracil, etc. PROCESS:An objective compound IV is prepared by reacting a compound with an alkali and an alkylating agent in a protonic solvent. The compound IV can be converted to another objective compound V by hydrolysis, and further converted to the other objective compound VI by protecting the OH groups and reacting with phosphoric sulfide.</p> |
