| 摘要 |
<p>Pharmaceutical compsn. contains 1-(2-nitro-5-methyl-phenoxy)-3-tert. butyl-aminopropan-2-ol (I) or an acceptable acid addition salt, together with a suitable diluent or carrier. (I) can be used as a tranquilliser and antihypertonic in the treatment of various heart and vascular diseases. (I) produces an excellent blocking of the beta-receptors of the sympathicus. (I) has a better inhibitory effect against the increased contractions strength and beat frequency induced by isoprenalin in an isolated heart auricle than has Propranol. ED50 for (I) is 4.0 x 10-8 g./ml., cf. the ED50 for Propranol, which is 2.0 x 10-7 g./ml. The compsn. can be in the form of tablets, capsules, dragees, solns., suspensions or emulsions for oral use, injectable solns. or emulsions, dispersible powders or aerosol, adn can also contain >=1 other pharmaceutical, chosen from sedatives, antihydpertonics, diuretics, vasodilators, antiarrhythmics, agents for treatment of Parkinson's disease, cardiotonic agents, bronchodilators and sympathomimetic agents.</p> |
