发明名称 |
A method of preparing a 2-hydroxy-3-isopropyl or a 2-hydroxy-3-tert-butylaminopropyl aromatic ether. |
摘要 |
Methods and intermediates for introducing the two blocking side chains, 2-hydroxy- 3-isopropyl or tert.-butylaminopropyl, into aromatic nuclei containing a phenolic hydroxyl group by condensing a 5-halomethyl-3-isopropyl or 3-tert. -butyl-2-oxazolidinone with an aromatic compound containing a phenolic hydroxy group in the presence of an acid binding agent at 80-150 DEG C then subsquently splitting the oxazolidinone ring using an alkali metal hydroxide or lower alkoxide at a temperature in the range of 100-150 DEG C in an organic solvent.
|
申请公布号 |
EP0008711(A1) |
申请公布日期 |
1980.03.19 |
申请号 |
EP19790102949 |
申请日期 |
1979.08.13 |
申请人 |
SMITHKLINE CORPORATION |
发明人 |
KIRKPATRICK, DAVID SAMUEL;WEBB, ROBERT LEE |
分类号 |
C07C67/00;C07C213/00;C07C217/30;C07D263/20;C07D263/24;C07D285/10;(IPC1-7):C07C93/06 |
主分类号 |
C07C67/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|