C-21 LOWER ALKYLSULFINYL ESTERS OF CERTAIN 21-HYDROXYCORTICOSTEROIDS

摘要

C-21 Lower alkylsulfinyl esters of certain 21-hydroxycorticosteroids are good antiinflammatory agents which have both topical and systemic activities. These compounds are best prepared by a 2-step process which involves the esterification of a 21-hydroxycorticosteroid with a lower alkylsulfide-acid and oxidation of the resulting sulfide ester with a mild oxidizing agent to the corresponding sulfinyl ester.