发明名称 |
Alpha-ethinyl-alpha-aminoacids and their esters, and pharmaceutical compositions containing them. |
摘要 |
Novel alpha -ethinyl- alpha -aminoacids having the formula <CHEM> wherein R has the signification given in the description and R1 is H or C1-C18 alkyl, e.g. the compounds of the formulas <CHEM> are prepared by reacting a derivative of the formula <CHEM> with sodium methoxide. The novel aminoacids are useful for treating hypertension, as gastric secretion inhibitors, antihistamine antiallergics and antitumor agents. Furthermore, they exhibit enzyme inhibition.
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申请公布号 |
EP0008658(A1) |
申请公布日期 |
1980.03.19 |
申请号 |
EP19790102618 |
申请日期 |
1979.07.24 |
申请人 |
MERCK & CO. INC. |
发明人 |
TAUB, DAVID;PATCHETT, ARTHUR ALLAN |
分类号 |
A61K31/403;A61K31/404;A61K31/405;A61K31/415;A61P9/12;A61P37/08;C07C43/225;C07C67/00;C07C227/00;C07C229/36;C07D209/08;C07D209/14;C07D209/20;C07D233/54;C07D233/64;C07F7/08;(IPC1-7):C07C101/72;C07C101/28;A61K31/19;A61K31/40;A61K31/41 |
主分类号 |
A61K31/403 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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