Process for stabilization of dicalcium phosphate

摘要

An improved process for the preparation of stabilized dicalcium phosphate dihydrate wherein an aqueous mixture containing dicalcium phosphate dihydrate is treated with a tetra-alkali metal pyrophosphate which comprises (a) adding a stabilizing amountof the tetra-alkali metal pyrophosphate to said aqueous mixture at a pH from about 5.5 to about 6.5 for said mixture; and then (b) adding to the mixture resulting from Step (a) a pharmaceutically acceptable material which increases the hydroxyl ion content in the mixture, in an amount which results in a stabilized dicalcium phosphate dihydrate having a pH from about 6.5 to about 8.0.