| 摘要 |
<p>Collagen, available from domestic animals, is freed of noncollagen proteins and glycoproteins, glycoasaminoglycans and lipids by treatment including enzymatically treating with a proteolytic enzyme to provide a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The collagen in solution is then treated according to a specific regimen (under conditions where the collagen in solution slowly comes out of solution while exposed to mild shear forces) resulting in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen having a natural appearing ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the NFM may be freed of salt, taken up in a different solution or modified. For example, cross links may then be introduced to stabilize the fibers. The products find wide use as packing, membranes, fibers, bags, supports, integuments, and ate especially suitable for biologic implantation or application.</p> |
