| 摘要 |
NEW MATERIAL:A compound of formula I: [R is formula III (R1 is H or 1-5C alkyl group); Ar is 1,2,3,4-tetrahydro-8-quinolyl group which may be substituted by at least one 1-5C alkyl group], and its pharmacentically acceptable salts. EXAMPLE:1-[ N<2>-( 1, 2, 3, 4-Tetrahydro-8-quinolinesulfonyl)-L-arginyl ]-4-methyl-2-piperidinecarboxylic acid. USE:Antithrombins and blood platelet antiagglutinating agents, having a selective inhibitory action on thrombin with low toxicity, useful as a reagent for determination of blood thrombin, or a remedy and preventive for thrombosis. PROCESS:A compound of formula X (R2 is H, alkyl group, etc.; Q is 8-quinolyl group, etc.), obtained from a compound of formula II, is reduced, and, if necessary, subjected to hydrogenolysis or hydrolysis to give the compound of formula I. |
