2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds, processes for their preparation and pharmaceutical compositions containing them.

摘要

A compound of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="22" wi="70" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><UnorderedLists id="ula01" listStyle="none"><ListItem>wherein R<Sup>1</Sup> is lower alkyl,</ListItem><ListItem>R<Sup>2</Sup> is carboxy or a protected carboxy group,</ListItem><ListItem>R<Sup>3</Sup> is amino or a protected amino group and</ListItem><ListItem>R<Sup>4</Sup> is lower alkyl having halogen atom(s) or lower unsaturated aliphatic group,</ListItem></UnorderedLists>
and pharmaceutically acceptable salt thereof, and process for their preparation.

The invention also relates to the starting derivatives and their preparation and to a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, and to a method for treating an infectious disease caused by pathogenes, which comprises administering the above compound to infected human beings or animals.