| 摘要 |
PURPOSE:To obtain a hair tonic, containing 1-O-(4-O-alpha-L-arabinofuranosyl-beta-D- glucopyranosyl)-1,2,3-propanetriol or a safflower extract solution containing the above- mentioned compound as an active ingredient and having preventive action on alopecia. CONSTITUTION:The objective substance, containing a novel compound expressed by the formula or a safflower extract solution containing the afore-mentioned compound and obtained by mixing a commonly used additive with a drug and preparing a pharma ceutical according to a conventional method. The hair tonic can be prepared in the form of a solution for external use, such an lotion, liniment or milky lotion, or semi solid agent for external use, such as cream, ointment, pasta, jelly or spray. The amount of the blended ingredient is 0.001-10wt.% compound expressed by the formula or 0.001-100wt.% safflower extract solution containing the above-mentioned compound. The percutaneous dose thereof is 0.0001-20mg/kg per day administered in 1-4 portions. The compound expressed by the formula is obtained by adding a water-soluble organic solvent to a hot water extract concentrate of safflower, fractionally precipitat ing the concentrate, passing the resultant supernatant through a chromatographic column and evaporation the obtained fraction to dryness under reduced pressure. |
