CONDENSED PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

摘要

Compounds of the formula I or pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers or tautomeric forms thereof are disclosed wherein R is hydrogen or lower alkyl R1 is hydrogen, lower alkyl, styryl, or a carboxylic acid; or R and R1 together form a group of the formula -(CH=CH)2- and in this case the broken line represents a further C-C bond, while in all other cases there is a single bond between positions 6 and 7; R2 is hydrogen, lower alkyl or hydroxy; R3 is hydrogen, lower alkyl, aryl, lower alkanoyl, carboxyl or a carboxyl acid derivative or a group of the formula -(CH2)m-COOH or a derivative thereof formed in the carboxylic group; n=1-3; R4 is hydrogen, lower alkyl which can be substituted by hydroxy or carboxy; trifluoromethyl, substituted or unsubstituted aryl, phenyl-lower alkyl or substituted or an unsubstituted heterocyclic group; R5 is hydrogen, lower alkanoyl, substituted or unsubstituted benzoyl or heteroaryl; or R4 and R5 together with the adjacent nitrogen atom form a piperidino, pyrrolidino or morpholino ring; or R4 and R5 together with the adjacent nitrogen atom form a group of the formula wherein R6 is hydrogen and R7 is substituted or unsubstituted phenyl; and Z is oxygen. The new compounds are useful for treating asthma.