Method and compositions of treating Parkinsonisms with levodopa and 3',4'-dihydroxy-2-methylisopropiophenone

摘要

Improved methods are provided for the treatment of the central nervous system dopamine-deficiency diseases (CNS-DADD's), including Parkinson's disease and other parkinsonisms, which comprises the administration of 3',4'-dihydroxy-2-methyl-isopropiophenone (DHMPP) in an amount effective to inhibit the conversion of levodopa to 3-O-methyldopa (OMD) by catechol-O-methyl transferase (COMT). The present method results in a reduction of the dosage of levodopa otherwise required to symptomatically control the CNS-DADD, providing a concomitant reduction in the untoward side effects of levodopa administration. Also provided are novel pharmaceutical compositions of levodopa and DHMPP.