(dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acids and derivatives and processes for the production thereof and their pharmaceutical compositions.

摘要

Novel 16-phenoxy and 18-(o, m or p)-substituted phenoxy derivatives of(dl)-9-keto-11α,15α-dihydroxy-17,18.19,20-tetranorprosta-4,5,13-trans-trienoic acid, the pharmaceutically acceptable, non-toxic lower alkyl esters and salts thereof and processes for the production of such compounds. These compounds possess prostaglandin-like activities and thus are useful in the treatment of mammals where prostaglandins are indicated. They are particularly useful as inhibitors of gastric acid secretion; and as agents for the control of asthmatic attack, because of their bronchodilating activity.