| 摘要 |
<p>7-.alpha.-(Imidarolidin-2-on-1-carbonylamido)acet-amido!-3-methylcaph- 3-em-4-carboxylic acids and 6-.alpha.-(imidazolidin-2-on-1-carbonylamido)acetamido!penicillanic acids, substituted in the 3-position of the imidazolidinone ring with cyclic structure and on the .alpha.-carbon atom of the acetamido bridge with a phenyl, thienyl, cyclohexenyl or cyclohexadiemyl group, and their salts, are prepared by acylation of an .alpha.-aminopenicillin or .alpha.-aminocephaloaporin, or, in the case of some cephalosporin derivatives, by treatment of the corresponding 3-acetoxymethylcephem with a mucleophilic reactant. The compounds, of which 7-.alpha.-(3-cyclopropylimidezolidin-2-on-1-ylcarbonylamino)phenyl-ace tamido!-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylic acid and .alpha.-3-(fur-3-yl)imidazolidin-2-on-1-ylcar-boxyamino!benzylpenicillin are representative examples, are antibacterial agents.</p> |
