发明名称 |
Derivatives of the D-threo-1-phenyl-2-trifluoroacetamido-1,3-propandediol |
摘要 |
A novel class of D-Threo-1-phenyl-1-trifluoroacetamido-1, 3-propanediols wherein the benzene ring is substituted in the para-position by methylmercapto or methanesulphonyl and the hydroxy moiety at position 3 of the prepanediol is acylated to afford alkanoyloxy, halo-alkanoyloxy or aminoalkanoyloxy. The instant products are prepared: (1) by treating a D-threo-1-(p-methanesulphonylphenyl)-2-amino-1,3-propanediol or a D-threo-1-(p-methylmercaptophenyl)-2-amino-1,3-propanediol with trifluoroacetic acid or with an ester derivative thereof; (2) by oxidation of the mercapto moiety in a D-threo-1-(p-methylmercaptophenyl)-2-trifluoroacetamido-1, 3-propanediol to afford the corresponding 1-(p-methanesulphonyl) derivative; or (3) by esterification of the 3-hydroxy moiety in a D-threo-1-phenyl-2-trifluoroacetamido-1, 3-propanediol precursor.
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申请公布号 |
US4188402(A) |
申请公布日期 |
1980.02.12 |
申请号 |
US19770822258 |
申请日期 |
1977.08.05 |
申请人 |
CLESA SPA |
发明人 |
CERVATO, GIUSEPPE;DELLABELLA, DAVIDE;MARCA, GIANFRANCO;PORTELLI, MARIO |
分类号 |
A61K31/165;(IPC1-7):A61K31/16 |
主分类号 |
A61K31/165 |
代理机构 |
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