发明名称 |
3'-HYDROXY-2-(SUBSTITUTED 1-ALKENYL)-5-OXOCYCLOPENTANE-1-HEPTANOIC ACIDS |
摘要 |
<p>7-3.beta.-hydroxy-2.beta.-(3-hydroxy-3-alkyl-1-alkenyl)-5-oxocyclopent ane!-1.alpha.-heptanoic acids and their alkyl esters are obtained by the reaction of an alkyl metal compound with a 7-3.beta.-hydroxy-2.beta.-(3-oxo-1-alkenyl)-5-oxocyclopentane!-1.alpha .-heptanoic acid wherein the 3.beta.-hydroxy group is preferably protected by an alcohol protecting group. When the indicated reaction is complete, any protecting group is removed and, if the ester is desired, the carboxylic acid is treated with an appropriate esterifying agent such as diazomethane. The prostaglandin derivatives so produced are valuable and useful as pharmacological agents as is evidenced by their anti-fertility activity.</p> |
申请公布号 |
CA1071625(A) |
申请公布日期 |
1980.02.12 |
申请号 |
CA19750223911 |
申请日期 |
1975.04.07 |
申请人 |
G.D. SEARLE & CO. OF CANADA LIMITED |
发明人 |
DORN, CLIFFORD R.;MIYANO, MASATERU |
分类号 |
A61K31/557;A61K31/5575;A61P43/00;C07C67/00;C07C401/00;C07C405/00;C07D309/12;(IPC1-7):07C177/00 |
主分类号 |
A61K31/557 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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