发明名称 |
4-[4-(Substituted)piperidino]quinazoline cardiac stimulants |
摘要 |
6,7-Dialkoxy-4-[4-(substituted)piperidino]quinazolines wherein the 4-substituent is -(CHR1)m-Z wherein R1 is hydrogen or lower alkyl; m is 1 or 2, with the proviso that when m is 2, each R1 can be the same or different; Z is -N(R2)COR3, -OCONR4R5, N(R2)SO2R3 or -N(R2)CONR4R5 wherein R2 is hydrogen or lower alkyl; R3 is lower alkyl, benzyl or phenyl; and each of R4 and R5 is hydrogen or is selected from group R3; and methods for their preparation. The compounds are phosphodiesterase inhibitors and cardiac stimulants.
|
申请公布号 |
US4188391(A) |
申请公布日期 |
1980.02.12 |
申请号 |
US19780954931 |
申请日期 |
1978.10.26 |
申请人 |
PFIZER INC |
发明人 |
CAMPBELL, SIMON F;DANILEWICZ, JOHN C;HAM, ALLAN L;STUBBS, JOHN K |
分类号 |
C07D211/26;A61K31/505;A61P3/00;A61P9/04;A61P43/00;C07D211/28;C07D213/38;C07D213/40;C07D213/42;C07D401/04;(IPC1-7):A61K31/50 |
主分类号 |
C07D211/26 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|