| 摘要 |
Polypeptides having the general formula: H-Tyr-X-Z-Y in which: X represents a chiral residue of a D-amino acid selected from D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-histidine, D-proline, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-aspartic acid, D-asparagine, D-lysine, and D-arginine; Y represents a hydroxy, amino, lower alkylamino, dilower alkylamino in which the lower alkyl groups contain 1 to 6 carbon atoms or a lower alkoxy group containing 1 to 6 carbon atoms; Z represents a segment of a mammalian beta lipotropin chain, beginning at chiral fragment 63 and containing 1 to 29 chiral fragments with the proviso that Z is not beta -lipotropin fragment 63 to 65; pharmaceutically acceptable salts thereof, their preparation and pharmaceutical compositions containing said polypeptides. |
