| 摘要 |
3-Thienyl-acetate derivatives of the general formula: <IMAGE> wherein R1 represents an alkyl, a cycloalkyl or an aralkyl radical, R2 represents hydrogen or R1 and R2, when they are taken together to form a cyclic group with the carbon atom to which they are attached, represent a polymethylene radical having from 2 to 5 carbon atoms, are prepared from a mixture consituted by a compound of the formula: <IMAGE> wherein R3 has the meaning given above and an organic halide of the formula: R4X wherein X represents fluorine, chlorine, bromine or iodine and R4 represents an alkyl, cycloalkyl or aralkyl radical or -CH2(CH2)nX in which n is an integer in the range of from 1 to 4 inclusive and X has the meaning given above, which mixture is added to an alkali metal hydride in dimethylformamide, at a temperature between -20 DEG C. and -5 DEG C., and allowed to react, in one step, at a temperature between -20 DEG C. and -5 DEG C. The 3-thienyl-acetate derivatives of formula I are useful as intermediate products for preparing pharmacologically active compounds.
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