发明名称 |
Chenodeoxycholic acid recovery process |
摘要 |
A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions separating the bile acids from the water-soluble constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions; isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxycholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, optionally purifying the chenodeoxycholic acid. The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.
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申请公布号 |
US4186143(A) |
申请公布日期 |
1980.01.29 |
申请号 |
US19780932176 |
申请日期 |
1978.08.09 |
申请人 |
CANADA PACKERS LTD |
发明人 |
ATTWELL, MICHAEL C;MASSIAH, THOMAS F;VERGOTTINI, ROBERTO A;ZIEGLER, PETER |
分类号 |
C07J9/00;(IPC1-7):C07J9/00 |
主分类号 |
C07J9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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