NEW PROCESS FOR THE PREPARATION OF 20-KETO-DELTA16-STEROIDS AND NEW INTERMEDIATE COMPOUNDS FORMED IN THIS PROCESS

摘要

The invention relates to a new process for the introduction into steroids of a 17-side chain containing a 20-keto group under the simultaneous formation of an unsaturated bond between C16 and C17 by reaction of 17-(isocyano-sulfonylmethylene)-steroids with an alkylating agent to 20-isocyano-20-sulfonyl-delta<1><6>-steroids, followed by hydrolysis of these latter compounds to 20-keto-delta<1><6>-steroids. The invention also relates to the intermediate compounds which are formed in this process, i.e. 20-isocyano-20-sulfonyl-delta<1><6>-steroids and to the ultimately formed 20-keto-delta<1><6>-steroids, as far as these latter compounds are new.