发明名称 MACROCYCLIC CHELATES AND METHODS OF USE THEREOF
摘要 The invention is a chelate of formula I: <IMAGE>ember selected from the group consisting of -NO2, -NH2, -NCS, -NHCOCH2-Z, with Z being a member selected from the group consisting of Br and I, -COOH; and -OCH2OOCH; and M is a metal ion selected from the group of elements consisting of Bi, Pb, Y, Cd, Hg, Al, Th, Sr, and Lanthanides. The invention also includes a chelate, wherein M is a copper ion and n is an integer from 2 to 5. The invention includes chelate conjugates of formula I and ligand conjugates of formula II: <IMAGE> The invention also includes methods to use these compounds for treatment of cellular disorders and for diagnostic tests.
申请公布号 AU3842889(A) 申请公布日期 1989.12.12
申请号 AU19890038428 申请日期 1989.05.24
申请人 US COMMERCE 发明人 OTTO A. GANSOW;MICHAEL A. MAGERSTADT;MARTIN W. BRECHBIEL
分类号 G01N33/532;A61K31/555;A61K49/00;A61K51/04;A61K51/08;A61K51/10;A61P35/00;C07D257/02;C07F3/00;C07F3/08;C07F3/12;C07F5/00;C07F5/06;C07F7/24;C07F9/94;C07F13/00;C07F15/02;C07F15/06;C07K4/00;C07K14/00;C07K14/52;C07K14/54;C07K14/55;C07K14/575;C07K16/00;C07K16/44;G01N33/534;G01N33/574 主分类号 G01N33/532
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