发明名称 |
Chemically modified endotoxin immunizing agent |
摘要 |
A bacterial endotoxin lipopolysaccharide of reduced toxicity covalently coupled to a protein antigen exhibits enhanced adjuvant effects. The coupling was affected by reaction with haloacylhalide. Lipopolysaccharide acylated with an anhydride of a dibasic acid is detoxified; in combination with endotoxin polysaccharide covalently coupled to protein antigen it developed synergistic immunogenic effects.
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申请公布号 |
US4185090(A) |
申请公布日期 |
1980.01.22 |
申请号 |
US19770807758 |
申请日期 |
1977.06.17 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
MCINTIRE, FLOYD C |
分类号 |
A61K39/385;A61K39/39;C08B37/00;(IPC1-7):A61K31/73;C07H5/06 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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