| 摘要 |
<p>Prostanoic acid derivatives of the following formula <IMAGE> are prepared, in which R' denotes an alkyl radical having 1-7 C atoms and R'' denotes a straight-chain alkyl radical having 6-9 C atoms. These compounds are obtained by reacting an appropriate ketone, which is optionally protected on the hydroxy group, with an organometallic compound of the formula R'M or R''M in which M denotes lithium or magnesium halogen to introduce the substituent R' or R'' and optionally subsequently removing the protective group. The compound of the formula I, which is present as the free acid, can be converted into alkyl esters having 1-7 C atoms in the alkyl radical. On account of their antifertility properties, the prostanoic acid derivatives are utilisable pharmaceutical agents.</p> |
